|
KMID : 0043320110340020217
|
|
Archives of Pharmacal Research
2011 Volume.34 No. 2 p.217 ~ p.222
|
|
|
In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens
|
|
Oh Ik-Hoon
Yang Woo-Young
Chung Soon-Chun
Kim Tae-Yoon
Oh Ki-Bong
Shin Jong-Heon
|
|
|
Abstract
|
|
|
|
A series of flavonoids (1?14) was isolated from the roots of Sophora flavescens. We evaluated their ability to inhibit both microbial growth and sortase A, an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus. Most prenylated flavonoids (7?13) displayed potent inhibitory activity against gram-positive and gram-negative bacteria except E. coli, with minimum inhibitory concentrations values ranging from 4.40 to 27.7 μM, and weak or no activity against fungal strains tested. Kurarinol (6) was a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. A preliminary structure-activity relationship, including essential structural requirements, is described.
|
|
|
KEYWORD
|
|
|
Sophora flavescens, Antibacterial activity Sortase A, Flavonoids, Kurarinol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|